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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - PFI-1

PFI-1

CAS No. 1403764-72-6

PFI-1 ( PF-6405761 )

Catalog No. M11688 CAS No. 1403764-72-6

PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PFI-1
  • Note
    Research use only, not for human use.
  • Brief Description
    PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay.
  • Description
    PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay.
  • Synonyms
    PF-6405761
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    BRD2; BRD4
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1403764-72-6
  • Formula Weight
    347.39
  • Molecular Formula
    C16H17N3O4S
  • Purity
    >98%(HPLC)
  • Solubility
    DMSO: 69 mg/mL (198.62 mM)
  • SMILES
    O=S(C1=CC=CC=C1OC)(NC2=CC3=C(NC(N(C)C3)=O)C=C2)=O
  • Chemical Name
    2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fish PV, et al. J Med Chem, 2012, 55(22), 9831-9837.
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